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‎_data/WP4018-bibliography.tsv‎

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ID Database Citation
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21613227 Pubmed "MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes. Dey N, Das F, Mariappan MM, Mandal CC, Ghosh-Choudhury N, Kasinath BS, et al. J Biol Chem. 2011 Jul 22;286(29):25586–603. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/21613227"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/21613227"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/21613227"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
3-
22306293 Pubmed "Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Gao X, Wang H, Yang JJ, Liu X, Liu ZR. Mol Cell. 2012 Mar 9;45(5):598–609. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/22306293"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/22306293"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/22306293"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
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23792563 Pubmed "Comprehensive molecular characterization of clear cell renal cell carcinoma. Cancer Genome Atlas Research Network. Nature. 2013 Jul 4;499(7456):43–9. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/23792563"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/23792563"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/23792563"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
5-
24058770 Pubmed "PKM2, STAT3 and HIF-1α: The Warburg’s vicious circle. Demaria M, Poli V. JAKSTAT. 2012 Jul 1;1(3):194–6. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/24058770"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/24058770"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/24058770"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
6-
24979721 Pubmed "Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration. Von Roemeling CA, Marlow LA, Radisky DC, Rohl A, Larsen HE, Wei J, et al. Oncotarget. 2014 Jul 30;5(14):5320–34. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/24979721"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/24979721"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/24979721"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
7-
25514926 Pubmed "PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/25514926"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/25514926"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/25514926"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
8-
27694978 Pubmed "Precision medicine from the renal cancer genome. Riazalhosseini Y, Lathrop M. Nat Rev Nephrol. 2016 Nov;12(11):655–66. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/27694978"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/27694978"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/27694978"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
9-
28329682 Pubmed "The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Nargund AM, Pham CG, Dong Y, Wang PI, Osmangeyoglu HU, Xie Y, et al. Cell Rep. 2017 Mar 21;18(12):2893–906. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/28329682"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/28329682"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/28329682"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
10-
40677703 Pubmed "Advances in immunotherapy and targeted therapy for advanced clear-cell renal cell carcinoma: current strategies and future directions. Wang B, Xiang Y, Liu X, Pan X, Peng L, Ma J. Front Immunol. 2025 Jul 3;16:1582887. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/40677703"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/40677703"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/40677703"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
2+
21613227 Pubmed "MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes. Dey N, Das F, Mariappan MM, Mandal CC, Ghosh-Choudhury N, Kasinath BS, et al. J Biol Chem. 2011 Jul 22;286(29):25586–603. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/21613227"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/21613227"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/21613227"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
3+
22306293 Pubmed "Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Gao X, Wang H, Yang JJ, Liu X, Liu ZR. Mol Cell. 2012 Mar 9;45(5):598–609. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/22306293"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/22306293"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/22306293"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
4+
23792563 Pubmed "Comprehensive molecular characterization of clear cell renal cell carcinoma. Cancer Genome Atlas Research Network. Nature. 2013 Jul 4;499(7456):43–9. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/23792563"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/23792563"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/23792563"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
5+
24058770 Pubmed "PKM2, STAT3 and HIF-1α: The Warburg’s vicious circle. Demaria M, Poli V. JAKSTAT. 2012 Jul 1;1(3):194–6. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/24058770"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/24058770"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/24058770"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
6+
24979721 Pubmed "Functional genomics identifies novel genes essential for clear cell renal cell carcinoma tumor cell proliferation and migration. Von Roemeling CA, Marlow LA, Radisky DC, Rohl A, Larsen HE, Wei J, et al. Oncotarget. 2014 Jul 30;5(14):5320–34. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/24979721"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/24979721"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/24979721"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
7+
25514926 Pubmed "PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/25514926"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/25514926"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/25514926"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
8+
27694978 Pubmed "Precision medicine from the renal cancer genome. Riazalhosseini Y, Lathrop M. Nat Rev Nephrol. 2016 Nov;12(11):655–66. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/27694978"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/27694978"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/27694978"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
9+
28329682 Pubmed "The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Nargund AM, Pham CG, Dong Y, Wang PI, Osmangeyoglu HU, Xie Y, et al. Cell Rep. 2017 Mar 21;18(12):2893–906. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/28329682"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/28329682"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/28329682"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
10+
40677703 Pubmed "Advances in immunotherapy and targeted therapy for advanced clear-cell renal cell carcinoma: current strategies and future directions. Wang B, Xiang Y, Liu X, Pan X, Peng L, Ma J. Front Immunol. 2025 Jul 3;16:1582887. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/40677703"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/40677703"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/40677703"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"

‎_data/WP4018-datanodes.tsv‎

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Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps
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PT-2385 Metabolite chebi:233314 ""
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Glucose Metabolite chebi:17234 "" wikidata:Q37525 chebi:17234 kegg.compound:C00293
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Belzutifan Metabolite pubchem.compound:117947097 "" wikidata:Q27456641 inchikey:LOMMPXLFBTZENJ-ZACQAIPSSA-N pubchem.compound:117947097 hmdb:HMDB0304835
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PT-2385 Metabolite chebi:233314 "" wikidata:Q27456687 chebi:233314 inchikey:ONBSHRSJOPSEGS-INIZCTEOSA-N pubchem.compound:91754484 chemspider:35308226
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Glucose Metabolite chebi:17234 "" wikidata:Q37525 chebi:17234
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Belzutifan Metabolite pubchem.compound:117947097 "" wikidata:Q27456641 inchikey:LOMMPXLFBTZENJ-ZACQAIPSSA-N pubchem.compound:117947097 chemspider:59053536 hmdb:HMDB0304835
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DEPTOR GeneProduct ensembl:ENSG00000155792 "" ensembl:ENSG00000155792 ncbigene:64798 hgnc.symbol:DEPTOR uniprot:Q8TB45
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ACACA GeneProduct ensembl:ENSG00000278540 "" ensembl:ENSG00000278540 ncbigene:31 hgnc.symbol:ACACA uniprot:A0A087WWN5;uniprot:A0A087WYS8;uniprot:A0A087X0W4;uniprot:A0A087X2F8;uniprot:A0A0C4DGT1;uniprot:Q59FY4;uniprot:A0A087WYK6;uniprot:A0A087X126;uniprot:Q13085;uniprot:A0A087WVR6;uniprot:A0A024R0Y2
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KCNJ2 GeneProduct ensembl:ENSG00000123700 "" ensembl:ENSG00000123700 ncbigene:3759 hgnc.symbol:KCNJ2 uniprot:P63252
@@ -36,9 +36,6 @@ BAP1 GeneProduct ensembl:ENSG00000163930 "" ensembl:ENSG00000163930 ncbigene:831
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KDM5C GeneProduct ensembl:ENSG00000126012 "" ensembl:ENSG00000126012 ncbigene:8242 hgnc.symbol:KDM5C uniprot:A0A8I5KPH7;uniprot:P41229;uniprot:A0A8I5KTT1;uniprot:F8WF56;uniprot:F8WDK1;uniprot:A0A8I5KXH7;uniprot:A0A6M4C8G8;uniprot:A0A8I5KQR8;uniprot:A0A8I5KYW1;uniprot:A0A8I5QL21
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TSC2 GeneProduct ensembl:ENSG00000103197 "" ensembl:ENSG00000103197 ncbigene:7249 hgnc.symbol:TSC2 uniprot:A0A2R8YDZ2;uniprot:A0A2R8Y5F1;uniprot:P49815;uniprot:A0A2R8YGU4;uniprot:H3BMQ0;uniprot:I3L3B1;uniprot:A0A2R8Y5B2;uniprot:A0A2R8YDR3;uniprot:H3BQY7;uniprot:X5D2U8;uniprot:A0A2R8YCR8;uniprot:A0A2R8Y670;uniprot:A0A2R8Y692;uniprot:A0A2R8Y6C9;uniprot:A0A2R8Y7C8;uniprot:A0A2R8YEJ8;uniprot:X5D7Q2;uniprot:I3L134;uniprot:A0A2R8Y7X5;uniprot:Q5HYF7;uniprot:A0A2R8YGD6;uniprot:A0A2R8YHA2;uniprot:A0A2R8YGE6;uniprot:H3BQK4
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PDGFB GeneProduct ensembl:ENSG00000100311 "" ensembl:ENSG00000100311 ncbigene:5155 hgnc.symbol:PDGFB uniprot:A9UJP0;uniprot:P01127;uniprot:A0A384NYY3;uniprot:A9UJN9
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TGFB1 GeneProduct ensembl:ENSG00000105329 "" ensembl:ENSG00000105329 ncbigene:7040 hgnc.symbol:TGFB1 uniprot:A0A7I2V5Z9;uniprot:A0A499FJK2;uniprot:A0A7I2YQL8
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TGFB2 GeneProduct ensembl:ENSG00000092969 "" ensembl:ENSG00000092969 ncbigene:7042 hgnc.symbol:TGFB2 uniprot:P61812
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TGFB3 GeneProduct ensembl:ENSG00000119699 "" ensembl:ENSG00000119699 ncbigene:7043 hgnc.symbol:TGFB3 uniprot:A0A6Q8PGK5;uniprot:A5YM40;uniprot:P10600
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CBP GeneProduct ensembl:ENSG00000005339 "" ensembl:ENSG00000005339 ncbigene:1387 hgnc.symbol:CREBBP uniprot:Q92793;uniprot:I3L466;uniprot:A0A1B0GUU0;uniprot:I3L3I5;uniprot:I3L0Q1;uniprot:I3L293
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AKT1S1 GeneProduct ensembl:ENSG00000204673 "" ensembl:ENSG00000204673 ncbigene:84335 hgnc.symbol:AKT1S1 uniprot:A0A024QZF6;uniprot:H9KV91;uniprot:M0R2V8;uniprot:Q96B36
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ACACB GeneProduct ensembl:ENSG00000076555 "" ensembl:ENSG00000076555 ncbigene:32 hgnc.symbol:ACACB uniprot:F8W8T8;uniprot:A0A087WUA1;uniprot:O00763;uniprot:F5H5C3;uniprot:S4R3S7;uniprot:H0YGH5

‎_pathways/WP4018.md‎

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parent: animal cell
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type: Cell Type Ontology
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value: kidney proximal convoluted tubule epithelial cell
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- id: PW:0000003
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parent: signaling pathway
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type: Pathway Ontology
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value: signaling pathway
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- id: CL:1000497
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parent: animal cell
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type: Cell Type Ontology
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parent: disease of cellular proliferation
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type: Disease Ontology
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value: clear cell renal cell carcinoma
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- id: PW:0000003
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parent: signaling pathway
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type: Pathway Ontology
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value: signaling pathway
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authors:
2020
- AlexanderPico
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- Khanspers
@@ -53,15 +53,15 @@ description: 'Inactivation of VHL due to mutation or DNA methylation is an early
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mTORC1 complex is based on [Wikipedia](https://en.wikipedia.org/wiki/Mechanistic_target_of_rapamycin#mTORC1).
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PDGFB and TGFB as targets of HIF1A based on [KEGG](http://www.genome.jp/kegg-bin/show_pathway?hsa05211). Phosphorylation
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sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.'
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last-edited: 2025-12-17
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last-edited: 2026-02-04
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ndex: 22a3a9b0-8b69-11eb-9e72-0ac135e8bacf
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organisms:
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- Homo sapiens
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redirect_from:
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- /index.php/Pathway:WP4018
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- /instance/WP4018
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- /instance/WP4018_r142204
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revision: r142204
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- /instance/WP4018_r142395
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revision: r142395
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schema-jsonld:
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- '@context': https://schema.org/
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'@id': https://wikipathways.github.io/pathways/WP4018.html
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- SQSTM1
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- SSPN
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- STAT3
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- TGFB1
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- TGFB2
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- TGFB3
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- TOX2
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- TPI1
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- TSC1

‎_pathways/WP4255.md‎

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parent: animal cell
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type: Cell Type Ontology
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value: bronchial epithelial cell
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- id: DOID:1749
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- id: PW:0000703
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parent: disease pathway
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type: Pathway Ontology
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value: lung cancer pathway
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- id: PW:0000013
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parent: disease pathway
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type: Pathway Ontology
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value: disease pathway
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- id: DOID:3908
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parent: disease of cellular proliferation
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type: Disease Ontology
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value: squamous cell carcinoma
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- id: DOID:3910
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value: lung non-small cell carcinoma
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- id: DOID:1324
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parent: disease of cellular proliferation
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type: Disease Ontology
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value: lung adenocarcinoma
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- id: DOID:4556
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value: lung cancer
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- id: DOID:1749
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parent: disease of cellular proliferation
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type: Disease Ontology
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value: lung large cell carcinoma
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- id: DOID:1324
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value: squamous cell carcinoma
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- id: DOID:3910
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parent: disease of cellular proliferation
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type: Disease Ontology
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value: lung cancer
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value: lung adenocarcinoma
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- id: PW:0000605
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parent: disease pathway
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type: Pathway Ontology
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value: cancer pathway
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- id: PW:0000703
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parent: disease pathway
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type: Pathway Ontology
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value: lung cancer pathway
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- id: DOID:3908
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- id: DOID:4556
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parent: disease of cellular proliferation
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type: Disease Ontology
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value: lung non-small cell carcinoma
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- id: PW:0000013
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parent: disease pathway
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type: Pathway Ontology
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value: disease pathway
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value: lung large cell carcinoma
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authors:
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- Khanspers
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- AlexanderPico
@@ -72,15 +72,15 @@ description: 'Non-small cell lung cancer (NSCLC) represents 85% of lung cancer a
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receptor whose function is often lost in NSCLC, leading to a loss of cell growth
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control. This pathway was developed based on [KEGG](https://www.kegg.jp/dbget-bin/www_bget?pathway+map05223).
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Phosphorylation sites were added based on information from [PhosphoSitePlus (R)](https://www.phosphosite.org).'
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last-edited: 2026-02-03
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last-edited: 2026-02-04
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ndex: 201c6ce2-8b6a-11eb-9e72-0ac135e8bacf
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organisms:
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- Homo sapiens
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redirect_from:
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- /index.php/Pathway:WP4255
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- /instance/WP4255
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- /instance/WP4255_r142393
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revision: r142393
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- /instance/WP4255_r142394
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revision: r142394
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schema-jsonld:
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- '@context': https://schema.org/
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'@id': https://wikipathways.github.io/pathways/WP4255.html

‎assets/img/WP4018/WP4018-thumb.png‎

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‎assets/img/WP4255/WP4255-thumb.png‎

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