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_data/WP3189-bibliography.tsv

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ID Database Citation
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9314612 Pubmed "Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH. Clin Pharmacokinet. 1997 Sep;33(3):214–24. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/9314612"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/9314612"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/9314612"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
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11823110 Pubmed "Felbamate-induced apoptosis of hematopoietic cells is mediated by redox-sensitive and redox-independent pathways. Husain Z, Pinto C, Sofia RD, Yunis EJ. Epilepsy Res. 2002 Jan;48(1–2):57–69. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/11823110"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/11823110"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/11823110"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
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9314612 Pubmed "Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH. Clin Pharmacokinet. 1997 Sep;33(3):214–24. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/9314612"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/9314612"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/9314612"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
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11823110 Pubmed "Felbamate-induced apoptosis of hematopoietic cells is mediated by redox-sensitive and redox-independent pathways. Husain Z, Pinto C, Sofia RD, Yunis EJ. Epilepsy Res. 2002 Jan;48(1–2):57–69. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/11823110"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/11823110"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/11823110"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"

_data/WP3189-datanodes.tsv

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Felbamate Metabolite hmdb:HMDB0015084 "" chebi:4995 inchikey:WKGXYQFOCVYPAC-UHFFFAOYSA-N pubchem.compound:3331 chemspider:3214 hmdb:HMDB0015084 kegg.compound:C07501
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2-hydroxyfelbamate Metabolite chemspider:8575477 "" wikidata:Q27149624 chebi:80583 inchikey:VTXNIAJKDLEHGX-UHFFFAOYSA-N pubchem.compound:10400039 chemspider:8575477 hmdb:HMDB0060670 kegg.compound:C16582
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CYP3A4 GeneProduct ensembl:ENSBTAG00000047379 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868"
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CYP2E1 GeneProduct ensembl:ENSBTAG00000018365 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130649" ensembl:ENSBTAG00000018365 ncbigene:282213 uniprot:A0A3Q1M6C2;uniprot:G3X7D6
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CYP2E1 GeneProduct ensembl:ENSBTAG00000018365 "HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130649"

_pathways/WP3189.md

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- Mkutmon
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- MaintBot
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- Eweitz
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description: CYP metabolism of felbamate.
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last-edited: 2021-05-21
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- Egonw
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citedin: ''
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communities: []
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description: CYP metabolism of felbamate, with the metabolites 2-hydroxyfelbamate,
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p-hydroxyfelbamate, and 3-Hydroxy-2-phenylpropylcarbamate. The last further metabolizes
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to 3-carbamoyl-2-phenylpropionaldehyde, atropaldehyde, and 3-carbamoyl-2-phenylpropionic
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acid.
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last-edited: 2026-02-17
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ndex: null
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organisms:
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- Bos taurus
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redirect_from:
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- /index.php/Pathway:WP3189
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- /instance/WP3189
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- /instance/WP3189_r117514
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revision: r117514
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- /instance/WP3189_r142450
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revision: r142450
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schema-jsonld:
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- '@context': https://schema.org/
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'@id': https://wikipathways.github.io/pathways/WP3189.html
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'@type': Dataset
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creator:
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'@type': Organization
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name: WikiPathways
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description: CYP metabolism of felbamate.
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description: CYP metabolism of felbamate, with the metabolites 2-hydroxyfelbamate,
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p-hydroxyfelbamate, and 3-Hydroxy-2-phenylpropylcarbamate. The last further metabolizes
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to 3-carbamoyl-2-phenylpropionaldehyde, atropaldehyde, and 3-carbamoyl-2-phenylpropionic
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acid.
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keywords:
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- 2-hydroxyfelbamate
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- 3-Hydroxy-2-phenylpropylcarbamate

assets/img/WP3189/WP3189-thumb.png

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