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‎_data/WP229-bibliography.tsv‎

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‎_data/WP264-bibliography.tsv‎

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ID Database Citation
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6867732 Pubmed "Choline and cholinergic neurons. Blusztajn JK, Wurtman RJ. Science. 1983 Aug 12;221(4611):614–20. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
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6867732 Pubmed "Choline and cholinergic neurons. Blusztajn JK, Wurtman RJ. Science. 1983 Aug 12;221(4611):614–20. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"

‎_data/WP264-datanodes.tsv‎

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Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps
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Phosphatidylethanolamines Metabolite chebi:16038 "" wikidata:Q426095 chebi:16038 kegg.compound:C00350 lipidmaps:LMGP02010000
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Phosphatidylethanolamines Metabolite chebi:16038 "" wikidata:Q426095 chebi:16038
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Cytidine diphosphate choline Metabolite chebi:16436 "" wikidata:Q28529682 chebi:16436 inchikey:RZZPDXZPRHQOCG-OJAKKHQRSA-N pubchem.compound:76963096;pubchem.compound:11583971;pubchem.compound:13804 chemspider:13207 hmdb:HMDB0001413 kegg.compound:C00307
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Phosphatidylcholines Metabolite chebi:49183 "" wikidata:Q75026757 chebi:49183 kegg.compound:C00157
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Phosphorylcholine Metabolite chebi:49183 "" wikidata:Q75026757 chebi:49183 kegg.compound:C00157
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Phosphatidylcholines Metabolite chebi:49183 "" wikidata:Q75026757 chebi:49183
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Phosphorylcholine Metabolite chebi:49183 "" wikidata:Q75026757 chebi:49183
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Glycerophosphocholine Metabolite chebi:16870 "" wikidata:Q28529699 chebi:16870 inchikey:SUHOQUVVVLNYQR-MRVPVSSYSA-N pubchem.compound:657272 chemspider:571409 hmdb:HMDB0000086 kegg.compound:C00670
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Choline Metabolite chebi:15354 "" wikidata:Q193166 chebi:15354 inchikey:OEYIOHPDSNJKLS-UHFFFAOYSA-N pubchem.compound:305 chemspider:299 hmdb:HMDB0000097 kegg.compound:C00114
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Acetylcholine Metabolite chebi:15355 "" wikidata:Q180623 chebi:15355 inchikey:OIPILFWXSMYKGL-UHFFFAOYSA-N pubchem.compound:187 chemspider:182 hmdb:HMDB0000895 kegg.compound:C01996
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Acetate Metabolite chebi:30089 "" wikidata:Q9154808 chebi:30089 inchikey:QTBSBXVTEAMEQO-UHFFFAOYSA-M pubchem.compound:175 chemspider:170 kegg.compound:C00033
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Acetate Metabolite chebi:30089 "" wikidata:Q9154808 chebi:30089 inchikey:QTBSBXVTEAMEQO-UHFFFAOYSA-M pubchem.compound:175 chemspider:170
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Acetyl CoA Metabolite chebi:15351 "" wikidata:Q715317 chebi:15351 inchikey:ZSLZBFCDCINBPY-ZSJPKINUSA-N pubchem.compound:444493 chemspider:392413 hmdb:HMDB0001206 kegg.compound:C00024 lipidmaps:LMFA07050281
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PDHA-1 GeneProduct ncbigene:3565996 "" ensembl:WBGene00011510 ncbigene:3565996 uniprot:P52899;uniprot:Q8I111
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PCYT-1 GeneProduct wormbase:WBGene00017241 "" ensembl:WBGene00017241 ncbigene:181021 uniprot:P49583;uniprot:Q3HKC4

‎_data/WP360-bibliography.tsv‎

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ID Database Citation
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6867732 Pubmed "Choline and cholinergic neurons. Blusztajn JK, Wurtman RJ. Science. 1983 Aug 12;221(4611):614–20. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://qlever.scholia.wiki/pubmed/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
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6867732 Pubmed "Choline and cholinergic neurons. Blusztajn JK, Wurtman RJ. Science. 1983 Aug 12;221(4611):614–20. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/6867732"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"

‎_data/WP360-datanodes.tsv‎

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Label Type Identifier Comment Ensembl NCBI gene HGNC UniProt Wikidata ChEBI InChI PubChem ChemSpider HMDB KEGG LipidMaps
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Phosphatidylcholine Metabolite chebi:49183 "" wikidata:Q75026757 chebi:49183 kegg.compound:C00157
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Pyruvate from Glycolysis Metabolite chebi:15361 "" wikidata:Q27089397 chebi:15361 inchikey:LCTONWCANYUPML-UHFFFAOYSA-M pubchem.compound:107735 chemspider:96901 kegg.compound:C00022
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Phosphatidylcholine Metabolite chebi:49183 "" wikidata:Q75026757 chebi:49183
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Pyruvate from Glycolysis Metabolite chebi:15361 "" wikidata:Q27089397 chebi:15361 inchikey:LCTONWCANYUPML-UHFFFAOYSA-M pubchem.compound:107735 chemspider:96901
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Phosphorylcholine Metabolite hmdb:HMDB0001565 "" chebi:18132 inchikey:YHHSONZFOIEMCP-UHFFFAOYSA-O pubchem.compound:1014 chemspider:989 hmdb:HMDB0001565 kegg.compound:C00588
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Acetate Metabolite chebi:30089 "" wikidata:Q9154808 chebi:30089 inchikey:QTBSBXVTEAMEQO-UHFFFAOYSA-M pubchem.compound:175 chemspider:170 kegg.compound:C00033
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Acetate Metabolite chebi:30089 "" wikidata:Q9154808 chebi:30089 inchikey:QTBSBXVTEAMEQO-UHFFFAOYSA-M pubchem.compound:175 chemspider:170
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Acetylcholine Metabolite hmdb:HMDB0000895 "" chebi:15355 inchikey:OIPILFWXSMYKGL-UHFFFAOYSA-N pubchem.compound:187 chemspider:182 hmdb:HMDB0000895 kegg.compound:C01996
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Acetyl-CoA Metabolite hmdb:HMDB0001206 "" chebi:15351 inchikey:ZSLZBFCDCINBPY-ZSJPKINUSA-N pubchem.compound:444493 chemspider:392413 hmdb:HMDB0001206 kegg.compound:C00024
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Cytidine Diphosphate Choline Metabolite chebi:16436 "" wikidata:Q28529682 chebi:16436 inchikey:RZZPDXZPRHQOCG-OJAKKHQRSA-N pubchem.compound:76963096;pubchem.compound:11583971;pubchem.compound:13804 chemspider:13207 hmdb:HMDB0001413 kegg.compound:C00307
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Phosphatidylethanolamine Metabolite chebi:16038 "" wikidata:Q426095 chebi:16038 kegg.compound:C00350 lipidmaps:LMGP02010000
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Phosphatidylethanolamine Metabolite chebi:16038 "" wikidata:Q426095 chebi:16038
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Choline Metabolite hmdb:HMDB0000097 "" chebi:15354 inchikey:OEYIOHPDSNJKLS-UHFFFAOYSA-N pubchem.compound:305 chemspider:299 hmdb:HMDB0000097 kegg.compound:C00114
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Glycerophosphocholine Metabolite chebi:16870 "" wikidata:Q28529699 chebi:16870 inchikey:SUHOQUVVVLNYQR-MRVPVSSYSA-N pubchem.compound:657272 chemspider:571409 hmdb:HMDB0000086 kegg.compound:C00670
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Pcyt1a GeneProduct ncbigene:140544 "" ensembl:ENSRNOG00000001762 ncbigene:140544 uniprot:P19836
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Pdha1 GeneProduct ncbigene:29554 "" ensembl:ENSRNOG00000025383 ncbigene:29554 uniprot:A0A0G2JW90;uniprot:F7FKI5
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Ahsg GeneProduct ncbigene:25373 "" ensembl:ENSRNOG00000038370 ncbigene:25373 uniprot:Q7TP75;uniprot:P24090;uniprot:F1LM19
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Ache GeneProduct ncbigene:83817 "" ensembl:ENSRNOG00000050841 ncbigene:83817 uniprot:A0A0G2K6V0;uniprot:M0R4A5;uniprot:Q505J2
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Chat GeneProduct uniprot:CLAT ""
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Pemt GeneProduct ncbigene:25511 "" ensembl:ENSRNOG00000054423 ncbigene:25511 uniprot:Q08388
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Pdha1 GeneProduct ncbigene:29554 "" ensembl:ENSRNOG00000025383 ncbigene:29554 uniprot:A0A0G2JW90;uniprot:A0A8I6GKV6;uniprot:F7FKI5
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Ahsg GeneProduct ncbigene:25373 "" ensembl:ENSRNOG00000038370 ncbigene:25373 uniprot:A0A8I5Y586;uniprot:Q7TP75;uniprot:A0A8I5ZY55;uniprot:P24090;uniprot:F1LM19
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Ache GeneProduct ncbigene:83817 "" ensembl:ENSRNOG00000050841 ncbigene:83817 uniprot:M0R4A5;uniprot:Q505J2
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Chat GeneProduct ensembl:ENSRNOG00000025012 "" ensembl:ENSRNOG00000025012 ncbigene:290567
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Pemt GeneProduct ncbigene:25511 "" ensembl:ENSRNOG00000054423 ncbigene:25511 uniprot:A0A8I6AJS4;uniprot:A0A8L2RBC3;uniprot:A0A8I6GAY9
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Pdha2 GeneProduct ncbigene:117098 ""

‎_pathways/WP229.md‎

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parent: native cell
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type: Cell Type Ontology
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value: enterocyte
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- id: CL:0000182
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parent: native cell
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type: Cell Type Ontology
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value: hepatocyte
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- id: PW:0001224
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parent: drug pathway
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type: Pathway Ontology
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value: irinotecan drug pathway
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- id: DOID:13250
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type: Disease Ontology
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value: diarrhea
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- id: DOID:1227
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type: Disease Ontology
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value: neutropenia
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- id: CL:0000182
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parent: native cell
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type: Cell Type Ontology
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value: hepatocyte
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- id: DOID:162
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parent: disease of cellular proliferation
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type: Disease Ontology
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value: cancer
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- id: DOID:1227
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type: Disease Ontology
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value: neutropenia
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authors:
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- 169.230.77.174
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- MaintBot
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has been associated with toxicity, further evidence is needed to describe the roles
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of ABCB1 variants in toxicity. Source: [PharmGkb](http://www.pharmgkb.org/search/pathway/irinotecan/liver.jsp). Proteins
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on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP229).'
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last-edited: 2026-02-12
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ndex: b1e18f20-8b61-11eb-9e72-0ac135e8bacf
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organisms:
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- Homo sapiens
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redirect_from:
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- /index.php/Pathway:WP229
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- /instance/WP229
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- /instance/WP229_r137113
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revision: r137113
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- /instance/WP229_r142439
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revision: r142439
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schema-jsonld:
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- '@context': https://schema.org/
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'@id': https://wikipathways.github.io/pathways/WP229.html

‎_pathways/WP264.md‎

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- Mkutmon
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- Fehrhart
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- Eweitz
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- Egonw
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citedin: ''
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communities:
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- WormBase_Approved
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description: Acetylcholine is an important neurotransmitter. It can be rapidly released
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in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound
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is degraded rapidly into choline and acetate, this is essential for proper neuronal
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functioning. Choline and Acetate are taken up into the cytosol and recycled for
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the next activation.
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last-edited: 2026-02-12
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ndex: null
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organisms:
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- Caenorhabditis elegans
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redirect_from:
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- /index.php/Pathway:WP264
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- /instance/WP264
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- /instance/WP264_r117857
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- /instance/WP264_r142438
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revision: r142438
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schema-jsonld:
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- '@context': https://schema.org/
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'@id': https://wikipathways.github.io/pathways/WP264.html

‎_pathways/WP360.md‎

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- Egonw
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- L Dupuis
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- Eweitz
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citedin: ''
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communities: []
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description: Acetylcholine is an important neurotransmitter. It can be rapidly released
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in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound
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is degraded rapidly into choline and acetate, this is essential for proper neuronal
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functioning. Choline and Acetate are taken up into the cytosol and recycled for
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the next activation.
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last-edited: 2026-02-12
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ndex: null
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organisms:
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- Rattus norvegicus
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redirect_from:
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- /index.php/Pathway:WP360
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- /instance/WP360
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- /instance/WP360_r116936
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- /instance/WP360_r142441
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schema-jsonld:
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- '@context': https://schema.org/
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‎_pathways/WP5298.md‎

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---
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annotations:
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- id: DOID:0080422
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parent: genetic disease
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type: Disease Ontology
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value: Dravet syndrome
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- id: CL:0011005
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parent: animal cell
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type: Cell Type Ontology
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value: GABAergic interneuron
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- id: CL:0000540
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parent: animal cell
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type: Cell Type Ontology
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parent: disease pathway
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type: Pathway Ontology
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value: disease pathway
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- id: CL:0011005
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parent: animal cell
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type: Cell Type Ontology
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value: GABAergic interneuron
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- id: DOID:0080422
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parent: genetic disease
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type: Disease Ontology
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value: Dravet syndrome
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- Pepinmarshall
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- Egonw
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of the voltage-gated sodium channel α subunit NaV1.1 in the of GABAergic inhibitory
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interneurons in the brain. Mutations in other genes like KCNA1, CHD2, PCDH19 and
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STXBP1 can also lead to Dravet syndrome. '
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ndex: null
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organisms:
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- Mus musculus
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- /index.php/Pathway:WP5298
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- /instance/WP5298
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- /instance/WP5298_r142362
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revision: r142362
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- /instance/WP5298_r142442
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revision: r142442
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schema-jsonld:
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- '@context': https://schema.org/
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'@id': https://wikipathways.github.io/pathways/WP5298.html

‎assets/img/WP229/WP229-thumb.png‎

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